Fortunately, TV Lineis reporting that there's at least one interesting Calzona plot coming up. As we've already reported, George O'Malley's (TR Knight) mom (played by Debra Monk) will be returning to Seattle Grace-Mercy West for surgery on Season 8, Episode 8: "Heart-Shaped Box" (November 3, 2011). According to Jessica Capshaw, Calzona will have a sweet “moment” with Ms. O'Malley during that episode.
Given George and Callie's romantic past, we're hoping Mama O'Malley takes the time to bestow her blessing on the newlyweds. That would be sweet, and an excellent way to honor George's memory (*sniff*).