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Meow! TV’s Top 12 Meanest Mean Girls

Every clique has a head b*tch in charge, and the cliques on TV are ruled by some of the cruelest of the cruel. It's not easy being Queen Bee; in fact, the role demands a well-honed set of skills: charm, manipulation, smug superiority, and mischievousness. From Blair Waldorf (Leighton Meester) to Brenda Walsh (Shannen Doherty), Wetpaint Entertainment has rounded up the most ferocious females in TV history. ;