It is definitely possible that one of the original cast members decided not to renew his or her contract for any number of reasons, and Shonda decided to end the character's story with a bang. On the other hand, it's possible that a non-original cast member was also in negotiations for some other reason, and that's what Jesse is hinting at.
What do you make of this clue? Do you think it means one of the originals is out? If so, does that make you more or less worried? Let us know in the comments!
Catch a new episode of Grey’s Anatomy on Thursday, May 10 at 9 p.m. ET/PT on ABC.