To start, here are the juiciest spoilers we've heard about the Little Liar who has suffered the most loss: Emily (Shay Mitchell).
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She's in her own world: Shay Mitchell told us that Emily is "in her own little world. The girls, obviously, are there for her, but they don't really understand what she's going through with [Maya's (Bianca Lawson) death]." We also know she spent the summer abroad, so she hasn't been around her friends for support much.
Does she move on? Marlene King has said that Emily will eventually move on from the loss of Maya, but it sounds like the process will take a while. Shay Mitchell says Emily starts the season not at all ready to jump back into the dating pool, and according to Marlene dealing with Maya's death will be a big part of Emily's emotional arc this season. Oh, and if you're wondering if Emily will go back to guys: Probably not, and almost certainly not in any long term way.