Given that Eric Dane (Mark Sloan) is supposed to leave the show after these two episodes, we have a bad feeling that he is going to die in the premiere. If that's true, than "Going Going Gone" could refer to Mark himself.
On the other hand, it could also be a hint that some of the docs actually do leave Seattle Grace-Mercy West for jobs elsewhere.
What do you make of this title? Let us know in the comments below!