The star went on Conan Thursday night to give the host an interview that the host will not soon forget.
It started out with Chris telling Conan about needing to get a spray tan for an episode of The Mindy Project, but the interview started to take a more revealing tone.
He tells the story of his spray tan, beginning with the arrival of the lady who is going to give him the tan.
"My wife was out for the night and I had my 3-year-old and my 4-year-old to myself," Messina said, "and this woman comes to the house that I'm just meeting for the first time and she brings me upstairs into my bathroom — my kids are watching some cartoon or what not — and she takes out a tent that's almost like a cage and she says 'Okay just take off all your clothes and I'll spray you down.' And I said 'Do you want me to cover my penis or do you want me to get a sock or what do you want me to do?'"
Chris then proceeded to act out the scene, saying that the spray tan lady then asked him to, "cup your balls, can you lift your balls."
Just use your imagination.
After Conan noted the star's openness about nudity, Chris began telling another story.
"I've done [nudity] in plays a lot," Chris said, "and when you're in a play you're backstage and you can kind of fluff a bit. You know what I mean?
Chris began explaining the differences between movies and plays, saying that in the movie 28 Hotel Rooms he was in the nude for a large part of the movie.
"The other day my wife was online and she pointed out a picture and she said 'look, this is a picture of you completely naked from '28 Hotel Rooms'" and my penis was about this big," he said, gesturing with his hands.
The playful back-and-forth between Conan and Chris didn't leave much to the imagination, and like the notorious penis picture, this interview will forever be a part of the Internet.