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The finale synopsis reads as follows:
Grey Sloan Memorial Hospital enters crisis mode as the storm rages, resources become scarce and patients flood in by the busload. Meanwhile, one of the doctors fights for their life.
As the Episode 23 synopsis revealed, Seattle is hit with a superstorm (think Hurricane Sandy) during the finale, which could lead to major problems for the hospital. That's the big danger.
As for the doc fighting for their life, we have a feeling that's Meredith (Ellen Pompeo), since the Episode 23 synopsis also warns that "one wrong move puts the lives of Meredith and her baby in jeopardy."