However, there have been many dearly departed cast members throughout the years, some actually perishing, and others disappearing for various reasons — sometimes voluntarily, sometimes not. Notably, Kate Walsh is not included because let’s be real: she’s coming back sometime.
Click through the gallery to see the five other saddest cast exits that hit us almost as hard as Sandra’s.
Alyse Whitney is an editor at Wetpaint Entertainment. Follow her on Twitter ;@AlyseWhitney.