Margaret Colin was born in Brooklyn, New York, and raised on Long Island. After graduating from college, Margaret began her acting career on the soap opera The Edge of Night, playing an heiress and former terrorist. She followed that with a longer stint on As the World Turns. Beyond the world of soaps, she has also been in a number of movies, including Something Wild, Three Men and a Baby, Independence Day, Unfaithful, and First Daughter. She is married to actor John Dreas, and they have two children. Interesting tidbit: a different actress was initially cast to play Eleanor Waldorf, Blair's mother—Colin didn't appear on the show until the fourth episode of Season 1.