Arizona (Jessica Capshaw) cheated on Callie (Sara Ramirez) with Dr. Lauren (Hilarie Burton) on last night's Grey's Anatomy Season 9, Episode 23: "Readiness Is All," and we're still trying to wrap our minds around it. Why did it happen? What does it mean for Callie and Arizona? Jessica Capshaw and Shonda Rhimes shared some thoughts about this twist on Twitter during and after the episode, and what they had to say wasn't entirely reassuring.

"East Coast ... It was begun for you," Jessica tweeted near the start of the episode. "Do you have reinforcements at the ready? Booze? Loved on? It gets real tonight. Real, real. really."

Shonda replied to that, "Jessica and I are (metaphorically) holding hand hand hoping you all make it through. This journey is BIG."

Then, after the episode, Jessica wrote,"I am gr8ful to play a character whose life & challenges r written honestly. Not perfectly. Let's all hold hands and see what happens next..."

Looks like holding hands is a theme, which makes sense. Calzona fans are about to jump into the unknown. Will we come out okay on the other side? It remains unclear.

Catch the Grey’s Anatomy Season 9 finale on Thursday, May 16, 2013, at 9 p.m. ET/PT on ABC.

Source: @JessicaCapshaw, @shondarhimes

Rebecca Martin is an editor at Wetpaint Entertainment. Follow her on Twitter @BeccaDMartin.