On Grey’s Anatomy, we’ve come to expect the unexpected. There are twists and turns every episode that trick us into thinking things will be great for a character, then have them come crashing down — sometimes literally, with planes. From the looks of it, Season 10 is no exception.

The new season kicks off filming today, July 17, and the two-hour premiere (which airs Thursday, September 26 at 9 p.m. ET) is going to be a doozy. Yes, we could have predicted that based on the previous nine seasons of Grey’s, but we got a confirmation from star Camilla Luddington (Jo Wilson), too.

Unprompted, the doc wrote about the upcoming season on Twitter, spilling unsettling commentary about what’s to come. She tweeted:

Does this mean “a lot” to take in for just Jo? Or Jo and Alex together? Or everyone? Considering that the first episode is a two-parter, that means twice the drama and twice the insanity, so we’re twice as nervous.

What do you think will happen in the Season 10 premiere? Leave your thoughts and theories in the comments below!