Grey's Anatomy fans were shocked by the news that Sandra Oh will be departing the show after Season 10, and many worry that she might not be the only original cast member who will opt to say goodbye once their contracts are up at the end of the season.

This got us thinking about the original cast members — along with Sandra, they are Patrick Dempsey, Ellen Pompeo, Chandra Wilson, Justin Chambers, and James Pickens Jr. and how much we'd miss them if they left. Each of the original characters brings a different certain something to the show, and they'd all leaving gaping holes if they chose to leave.

However, not all characters are made equal, and every fan has his or her favorite. So, we want to know: Between Meredith, Derek, Cristina, Bailey, Alex, and Richard, whose departure would break your heart the most?

Can you not imagine Grey's without the titular protagonist and her signature monologues opening each episode? Is the show just too dreary without McDreamy? Is Bailey truly the heart of the hospital for you? Do you need Richard's wisdom, Cristina's snark, or Alex's grumpiness?

We know this is a hard choice, but we want you to weigh in: Which character would you miss the most?

Vote in our poll, and sound off in the comments below!

For more Grey’s spoilers, click here.

Catch the Grey’s Anatomy Season 10 premiere on Thursday, September 26, 2013, at 10 p.m. ET/PT on ABC.

Rebecca Martin is an editor at Wetpaint Entertainment. Follow her on Twitter @BeccaDMartin.