Grey's Anatomy has kept us entertained and emoting for nearly nine years now, but all good things must come to an end, and everyone wants to know when and how Grey's will leave the air, especially considering the tenuous hold it has on its biggest stars, one of whom is leaving next year.

Now, as Grey's ramps up for Season 10, three of the show's MVPs are contemplating its longevity and future through interviews with TV Guide.

Patrick Dempsey (Derek Shepherd), for one, sees Grey's as a show that can endure for many more seasons, regardless of any cast turnover: "You look at ER, and it went on for 15 years, and a lot of the original cast was gone from there. Because [Grey's is] such a procedural, I think it will continue to go on."

Sara Ramirez (Callie Torres), meanwhile, seems both nervous and optimistic for the future. "Of course, change can be uncomfortable," she says. "But I am choosing to stay hopeful that the writers will continue to be inspired by everyone who is still here and that their creative juices will keep flowing in a way that feels right for the show and for the fans."

And Ellen Pompeo (Meredith Grey) reflects on the show's appeal to multiple generations of TV viewers, saying, "We have an amazing fan base. Many of the show's viewers have been following the series since the beginning … We have this whole other group of young people who are 13- or 14-year-olds — I'm always reminded on Twitter how young they are — that are just discovering the show and watching all nine seasons on Netflix all at once."

"The show has had this incredible resurgence with a whole other generation, which we're extremely grateful for," Ellen continues.

It also undoubtedly helps that Grey's doesn't feel hopelessly dated when you look back at Season 1 — here's looking at you, ER — since today's technology and style aren't so different than that of 2005. So as long as the show remains instantly accessible (and binge-able) on Netflix, new viewers have little reason to not check in to Seattle Grace Mercy West/Grey Sloan Memorial.

Additionally, the show's revitalizing Season 7 — during which the docs grappled with the fallout of the shooting — proved that Grey's, while perhaps past its heyday, can still deliver engaging and thoughtful drama which can attract and keep viewers.

Do you think Season 10 will silence any skeptics? Or do you think ABC and the writers should think about pulling the plug? Share your prognoses below!

Source: TV Guide

Credit: HuffPost TV Photo: Chandra Wilson and Sara Ramirez on "Messy" Season 10 (VIDEO)
Dan Clarendon is an assistant editor at Wetpaint Entertainment. Follow him on Twitter and Google+!