In a game called "Spill the Anatomy," Andy peppered the 43-year-old star with invasive questions about her co-stars.
"Patrick Dempsey," Ellen replies without hesitation.
"Uh, we don't have that much time," Ellen gushes.
Then Andy starts applying the heat! Who does Ellen miss most: T.R. Knight (George O'Malley), Katherine Heigl (Izzie Stevens), or Isaiah Washington (Preston Burke)? "T.R. and Katie are kinda the same person. So, T.R. and Katie. They're a sandwich!" Ellen answers.
Which Grey's moment was worse: Izzie's sex with Ghost Denny or the musical episode? "The musical episode!" Ellen says.
Here comes the clincher! "Bigger b—h to work with?" Andy inquires. "Katherine Heigl, Isaiah Washington?"
"Isaiah all the way!" Ellen laughs.
Burn! But considering the circumstances behind Isaiah's exit, we're not surprised!
Did Ellen reveal too much, or was she refreshingly candid? Let us know in the comments below!