Grey's Anatomy's Season 10 premiere was heavy on the relationship drama… especially when it came to Callie (Sara Ramirez) and Arizona (Jessica Capshaw). And while we — unsurprisingly — didn't get any resolution between our favorite (estranged) couple, it seems that things are going to get worse before they get better.

According to Sara and Jessica, however, there's a possibility they may never get better.

From the beginning of their relationship, their chemistry was undeniable — but could their seemingly eternal flame have gone out early?

"I don't know what to think based on what's unfolding, and I think that's not an accident," Sara told TV Guide. "When things get this messy, it takes time to unravel what's happened and what's behind it. What's truly underneath it all?"

And Jessica seems to think there may be no going back to the way things were before for Calzona.

"You're in a relationship that's a choice, and it's how you show up in that relationship that defines how and what your relationship is made of," she said. "Who knows if they're made for each other? Right now, they're not making decisions that would indicate that."

"I certainly wouldn't want to be made for someone who was able to sleep with someone so callously," Jessica added in Callie's defense. "They've got some stuff to do."

Do you think that, despite Arizona's infidelity, Calzona are still made for each other? Weigh in below.

Source: TV Guide