After Grey’s Anatomy’s 200th episode, Callie Torres and Arizona Robbins weren’t in a good place. They were completely separated, both physically (Arizona hiding in a closet drinking the night away with April Kepner) — and emotionally (with Callie telling donors that her wife had died in the plane crash). And unfortunately, it sounds like the rest of Season 10 won’t fare well for them either.

In true Shonda Rhimes fashion, she tweeted a cryptic spoiler on October 10 about Calzona. “Yesterday we did table read for @GreysABC episode that is going to blow the minds of Calzona fans. And that's all the spoiler I'm giving,” she wrote. With Shonda, it’s a 50/50 when it comes to “mind-blowing” being good or bad, but we’re leaning toward the latter after reading a second juicy teaser.

“Cast read thru of Episode 1009 — writer Stacy McKee did a fantastic job! What happens when one of our docs makes a tragic mistake?” writer and co-showrunner Tony Phelan tweeted. Tragic mistake? Is that Calzona, too, or is it another doctor’s relationship or operation problem. It could be botching a patient’s surgery, misdiagnosing someone, or hurting their loved one. On Grey’s, it can be any of the above — or all of them at the same time.

While we understand that Callie and Arizona can’t get back together immediately, we hope they’re on the road to a better place this season. What do you think will happen with them? Leave your thoughts and theories below!

Catch Grey’s Anatomy on Thursdays at 9 p.m. ET on ABC.

Alyse Whitney is Assistant Editor at Wetpaint Entertainment. Follow her on Twitter and Google+.