Update (March 4, 2013): Thanks to a just-released synopsis from ABC, we know that Paul shows up as early as Season 10, Episode 16 — "We Gotta Get Out of This Place," airing March 20 — playing Meredith's research assistant. And by the looks of these photo from the episode, it looks like he and Stephanie (Jerrika Hinton) get into trouble!
Original story (January 24, 2013): Paul James has graduated from college and headed to a prestigious research job in Seattle! The actor — best known for his role as Calvin in ABC Family's fraternity-sorority dramedy, Greek — is joining the cast of Grey's Anatomy as a guest-star for a Season 10 episode, with the potential to stay for longer!
In breaking the news, TVLine also reports that his character "comes to the hospital to assist with research." Maybe Meredith is getting a new protege? Maybe Derek needs help with his presidential brain-mapping initiative?
Besides his Image Award-nominated Greek gig, Paul has appeared in Bones, Torchwood, Shameless, and a little-seen Sarah Jessica Parker movie called Spinning Into Butter.
Paul isn't the first Greek star to pop up in Shondaland Seattle. Amber Stevens played a one-night-stand of Alex's (Justin Chambers) in a Season 7 episode — which complicates things since her Greek character, Ashleigh, is an avid Grey's Anatomy fan. So, what, did Ashleigh watch Grey's that week and see her long-lost twin?
This is what happens when you reference TV shows in other TV shows.
In any case, we're looking forward to Paul's appearance — and hoping he sticks around!