If there’s something to be said for finding love in a hopeless place, then Grey's Anatomy’ stud Alex Karev (Justin Chambers) deserves to find it.

After seasons of one-night stands and heartbreak (Ava/Rebecca, Izzie, etc.), we think Alex deserves a little happiness. Enter intern Jo (Camilla Luddington).

Has Alex finally met his match in Seattle Grace’s new smart-mouth intern? We think so! Here are five reasons Alex and Jo work as a couple … no offense, Izzie (Katherine Heigl).

1) They have similar backgrounds: No one can understand how the foster-care system affects a child better than someone who has been through it. Jo and Alex not only share the same emotional scars, but they find ways to use them for fun (i.e. crying as a method to sneak into a hotel suite).

2) She makes him laugh: When was the last time we saw Alex Karev genuinely laugh? George’s (T.R. Knight) funeral? We can’t even tell you, to be honest. But we loved seeing him  crack up at Bailey’s (Chandra Wilson) wedding. Loved it.

3) She’s got a thick skin: When we first met Jo, we thought she cried too much. But now we learned she was faking it to get what she wanted … and we can respect that. No matter how much Alex loves someone, he’s probably going to say something ridiculously hurtful at some point, so having a thick skin is a necessity for dating a Karev.

4) Her dark sense of humor: At the end of the day, Alex is one of the most dark-and-twisty characters on the show … if not the most dark-and-twisty. But the fact that Jo can talk about those tough issues and joke about them at the same time means she’s kind of dark-and-twisty too. Laughter is how you survive the dark stuff. We learned that from Izzie. Awkward.

5) She’s hot (but rough around the edges): We love Alex, but he’s always been a superficial guy. Remember his short-lived career in Plastics? Let’s face it: He’s not going to date someone who’s unattractive. Luckily for Jo, she doesn’t have to worry about that. However, Alex also can’t get serious with someone who’s perfect. So believe it or not, Jo’s emotional scars (or whatever you want to call them) actually work in her favor.

We know Izzie didn’t have an easy upbringing, and she had spunk and a thick skin too. That’s why Alex loved her so much. But ultimately, Izzie and Alex were both a little too selfish in their relationship, and we think Alex learned from that. Plus, the fact that Jo is similar to Izzie but without some of the selfish, overly confident tendencies, means she’s exactly what the doctor ordered for our favorite dark-and-twisty doc.

Do you think Jo and Alex will end up together?

Catch the next new episode of Grey’s Anatomy on Thursday, January 17, 2013, at 9 p.m. ET/PT on ABC.

Samantha Highfill is a contributing writer to Wetpaint Entertainment. Follow her on Twitter at @samhighfill.