Credit: Richard Cartwright/ABC Television Group © 2011 Disney Photo: Meredith, Cristina, Jackson, and Alex on Grey's Anatomy September 29, 2011

The fifth year residents finally get to take the reins as lead surgeons on Grey's Anatomy Season 8, Episode 3, "Take the Lead." Who will flourish under pressure, and who will fail? And also, will Derek (Patrick Dempsey) ever trust Meredith (Ellen Pompeo) with anything ever again? We'll find out next week!

Credit: YouTube Photo: Watch! Grey's Anatomy Season 8, Episode 3 Preview: Residents in Charge

Catch Grey’s Anatomy Season 8, Episode 3 on September 29 at 9 pm ET/PT on ABC.