Credit: ABC Family Channel © Disney ABC Television Group

Grey's Anatomy shippers should know by now that they are never safe. Despite the fact that Shonda Rhimes has said time and again that Meredith (Ellen Pompeo) and Derek (Patrick Dempsey) are in it for the long hall, their relationship could possibly be at risk come season’s end.
 
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TVLine has given us yet another blind item, and we have cause to believe that it could be about two of our favorite Seattle Grace-Mercy West docs. (After all, the last one was.)

TVLine states that a major beloved couple in an hour-long drama will call it quits before heading into what could be the show’s last season. They narrow it down to nine possibilities, and the list includes MerDer and Callie (Sara Ramirez) and Arizona (Jessica Capshaw).

The split is described as an unexpected jolt that would give the writers a lot of creative opportunities going into the next season.

Could Meredith and Derek give up on their marriage? If so, why? And what about Calzona? Will they ever recover from the effects of the plane crash?

We have a hard time imagining either couple calling it quits, but it is possible Grey's will end next season, and this is Shondaland...

Catch the next new episode of Grey’s Anatomy on Thursday, January 10, 2013, at 9 p.m. ET/PT on ABC.

Source: TVLine

Samantha Highfill is a contributing writer to Wetpaint Entertainment. Follow her on Twitter at @samhighfill.