If there’s one thing we know about Grey’s Anatomy, it’s that relationships are always in jeopardy. No matter how in love a couple is, we’re always waiting for the other shoe to drop, and unfortunately, someone’s sneaker is hitting the hospital floor sooner rather than later.

According to TV Guide, there’s a big breakup coming up in Season 9, with one of the Grey Sloan Memorial Hospital couples “calling it quits after some seriously dishonesty in the relationship.”

Let’s break it down: the current couples are Meredith and Derek, Cristina and Owen, Callie and Arizona, Bailey and Ben, Jackson and Stephanie, Richard and Catherine, April and Matthew, and Jo and Jason. (Sorry, Alex!)

MerDer fans can breathe easy, because TV Guide’s Natalie Abrams promises it’s not them. Though any number of the docs could be lying to each other, since Sarah Drew told us that the truth about her virginity “will come out, and there will be difficult consequences” with Matthew, we have a feeling these two are headed for Splitsville.

However, with Catherine and Richard’s relationship on the fritz and Jackson and April still harboring feelings for each other, maybe there will be a trifecta of breakups. You know what they say — bad things come in threes!

Do you think April and Matthew will break up, or can they stand the test of time? Sound off below.

Catch the next episode of Grey’s Anatomy tonight, Thursday, March 21 at 9 p.m. ET on ABC.

Source: TV Guide

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Catch the next episode of Grey's Anatomy tonight, Thursday, March 21, 2013 at 9 p.m. ET on ABC. 

Alyse Whitney is an editor at Wetpaint Entertainment. Follow her on Twitter @AlyseWhitney.