Credit: Danny Feld / ABC Photo: Mark and Derek on Grey's Anatomy Season 9

Grey's Anatomy is good at a lot of things: giving us memorable romantic moments (longing looks, passionate kisses, etc.), producing top-notch dramatic voice overs, showcasing preternaturally beautiful surgeons, and, of course, making us cry.

So in light of the show's latest tragic loss, we want to punish (but also reward) ourselves with a look back at some of the saddest deaths ever to hit Grey Sloan Memorial… leading up to what's still the freshest wound: Derek (Patrick Dempsey).

Here are our picks for 10 of Grey’s Anatomy’s saddest deaths:

George’s dad: The death of George's (T.R. Knight) father on Grey’s was sad for many reasons. For one, the long, drawn-out goodbye was devastating. Two, we loved George so much. And three, it caused him to make a rash decision in marrying Callie (Sara Ramirez). And we all know how that turned out.

Any and every child: We hate it when kids die on the show, which unfortunately, has happened a number of times. But we will never forget the little girl in Season 5. She was Bailey’s (Chandra Wilson) patient, and her father was trying to get her to Mexico for experimental surgery. Instead, he ended up holding her and describing the sandy beaches of Mexico to his little girl as she took her last breath. Yea, that one. Excuse us while we go get a tissue.


Adele (Loretta Devine): Because of Adele's dementia, we'd seen this death coming for a long time, but that didn't make the demise of Mrs. Richard Webber any less sad... especially when Richard (James Pickens Jr.) imagined himself dancing with her during Bailey's wedding.

Henry (Scott Foley): We never liked Teddy (Kim Raver) more than when she was with Henry. They were an unlikely pair, but they were the happiest married couple on the show albeit for a short time. And then Cristina (Sandra Oh) the robot surgeon let Henry go without even knowing it, Owen (Kevin McKidd) didn’t tell Teddy, and drama ensued.

Doc: Did anyone else sob hysterically when Derek and Meredith (Ellen Pompeo) put Doc to sleep? Yes he was symbolic, but he was also just a sweet dog. Just us? OK.

Denny (Jeffrey Dean Morgan): You knew it was coming. Between the love we had for Denny himself to Katherine Heigl’s amazing performance, losing Denny hit us where it hurt. 

George:
It’s almost too painful to talk about this one. Yes, it was a fantastic twist. But we will never forget the look on Meredith’s face when she figured out that hit-by-a-bus guy was George, or more specifically, 007. Ugh. Guys, he was dragged for blocks. We can’t. We just can’t.

Lexie (Chyler Leigh): It was sudden. It was unexpected. It was downright heartbreaking.

Mark (Eric Dane): Because apparently breaking out heart over Lexie wasn't enough.

Derek: We only had a few days to prepare for this death after reports emerged that Patrick was leaving the show. We never thought we'd see a permanent end to MerDer, the show's original power couple, but sometimes actor departures cause an abrupt change in a show's trajectories.

What do you think has been the saddest death in Grey’s Anatomy history? Let us know in the comments below!

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