25. Cristina and Burke’s Wedding (Grey’s Anatomy)
When Dr. Burke (Isaiah Washington) proposed to Cristina (Sandra Oh), we didn’t really expect them to get married. After all, she wasn’t exactly a romantic. But then in an unexpected and poignant twist, it was Cristina who was left at the altar when Burke decided she wasn’t the person he wanted to end up with. Sniff... Still, we can’t help but wonder if this ill-fated twosome would’ve enjoyed a happily ever after if Isaiah hadn’t gotten himself kicked off the show in real life. D’oh!