Grey’s Anatomy: Lexie Grey and Mark Sloan
When: The Season 8 finale, “Flight”
How: Lexie (Chyler Leigh) dies in the aftermath of a devastating plane crash, having been pinned under the tail of the plane.
Air travel will never be the same again.
When: The Season 9 premiere, “Going, Going, Gone”
How: Having fallen into a coma post-plane crash, Mark (Eric Dane) passes on to the Seattle Grace Mercy West in the sky when the docs pull the plug after 30 days, according to his wishes.