5. Alex and Izzie/Meredith and Derek’s Wedding (Grey’s Anatomy)
When Izzie (Katherine Heigl) took the reigns on planning Meredith (Ellen Pompeo) and Derek’s (Patrick Dempsey) nuptials, they couldn’t say no to anything. (Brain tumor = ultimate trump card.) She became a complete bridezilla, turning it into her dream wedding. Luckily, Alex (Justin Chambers) was a willing groom, so a list-minute switcheroo made it hers after all. While they enjoyed the pomp and circumstance, Meredith and Derek swapped vows on a Post-it note. Everyone got what they wanted... temporarily. At least we have the memories!